Revolutionizing Drug Discovery: Advancements and Future Prospects in Immune-Competent Human Skin Disease Models

EasyChair Preprint 12153, version 2

Abstract

Skin diseases, inherently entailing a substantial immune component, pose a considerable challenge in drug development due to disparities between animal and human immunology. This comprehensive review delves into the landscape of immune-competent human skin disease models, focusing on their significance in advancing drug discovery. Addressing key issues in current models, such as poor prediction of human immune responses, the review navigates through innovative in vitro alternatives, emphasizing co-cultures and 3D organotypic systems. Diseases like fibrosis, autoimmune disorders, psoriasis, cancer, and contact allergy are spotlighted, providing a detailed analysis of pathology and available models. The limitations of existing models underscore the necessity for superior non-animal, human immune-competent, and scalable skin disease models featuring comprehensive biomarkers. Furthermore, this review directs attention to areas requiring future development, including the integration of diverse immune cells and scalability. The urgent demand for accurate drug discovery methodologies that align with ethical guidelines, such as the 3Rs (reduction, refinement, and replacement of animals in experiments), is highlighted.

Keyphrases: Human Skin Disease Models, Humanize Mouse, drug discovery

@booklet{EasyChair:12153,
  author    = {Arti Shukla},
  title     = {Revolutionizing Drug Discovery: Advancements and Future Prospects in Immune-Competent Human Skin Disease Models},
  howpublished = {EasyChair Preprint 12153},
  year      = {EasyChair, 2024}}