In Silico Testing on the Activity of Flavonol in Sterculia Foetida Leaf as Natural anti Hyperlipidemia Compounds

EasyChair Preprint 7199

Abstract

This study aimed to determine the bioactivity of flavonol in Sterculia foetida leaf as an antihyperlipidemic drug. The chemical structure of the flavonol contained in Sterculia foetida leaf was taken from the literature. The target protein used was 3-hydroxy-3-methylglutaryl-coenzyme A reductase, while the control  was simvastatin. Water molecules were removed using PyMol v2.5.2 Software. Docking between the target protein and flavonol was performed using PyRx-Python Prescription 0.8 Software. The results showed that flavonol compounds had greater potential as antihyperlipidemic compared to control compounds. The comparative affinity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase with flavonols is -8, 3 while the affinity for 3-hydroxy-3-methylglutaryl-coenzyme A reductase with simvastatin is -7.9. Toxicity test of flavonol showed that the flavonol was not potentially carcinogenic and did not cause mutations. The absorption of flavonol in water was higher than in the control compound.

Keywords: anti hyperlipidemia, sterculia foetida, flavonol, 3-hydroxy-3-methylglutaryl-coenzyme A reductase

Keyphrases: 3 hydroxy 3 methylglutaryl coenzyme A reductase, Anti-hyperlipidemia, Sterculia foetida, flavonol

@booklet{EasyChair:7199,
  author    = {Nindrahayu Nindrahayu and Andi Ariyandy and Ika Yustisia and Sulfahri Sulfahri},
  title     = {In Silico Testing on the Activity of Flavonol in Sterculia Foetida Leaf as Natural anti Hyperlipidemia Compounds},
  howpublished = {EasyChair Preprint 7199},
  year      = {EasyChair, 2021}}