Download PDFOpen PDF in browserIn-Silico Test of Activity Apigenin as a Natural Compound in Reducing Uric Acid LevelEasyChair Preprint 71974 pages•Date: December 9, 2021AbstractThis study aims to determine the bioactivity of these compounds apigenin on Apium graveolens as a medicine lowering uric acid levels. Chemical structure of compound apigenin contained in Apium graveolens taken from the literature. The target protein used is Interleukin 17-A. Water molecules were removed using PyMol v2.5.2 Software. Docking between the target protein and the compound was performed using PyRx-Python Prescription 0.8 Software. The results showed that the compound apigenin has a greater potential for lowering uric acid levels compared to control compounds. The affinity value of Interleukin 17-A with Apigenin is -6.4 while the affinity value of Interleukin 17-A with Allopurinol is -4.8. Compound toxicity test Apigenin The results showed that this compound was not a potential carcinogen. Keyphrases: Allopurimol, Apigenin, Apium graveolens, Interleukin-17A
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