Development and Characterization of a Novel Human Skin and Immune System (hSIS)-Humanized Rodent Model for Studying Skin Pathogen Infections

EasyChair Preprint 12134

Abstract

The human skin, as the primary barrier against pathogen transmission, is a key focus in infectious disease research. Despite the utility of rodent models in studying human-specific skin pathogens, achieving successful co-engraftment of human skin, autologous lymphoid tissues, and immune cells remains a challenge. In this study, we introduce the development of a novel human Skin and Immune System (hSIS)-humanized NOD-scid IL2Rγnull (NSG) mouse and Sprague–Dawley-Rag2tm2hera Il2rγtm1hera (SRG) rat models, involving the co-engraftment of human full-thickness fetal skin, autologous fetal lymphoid tissues, and autologous fetal liver-derived hematopoietic stem cells.

Keyphrases: Human skin, Humanized Rodent Model, immune system

@booklet{EasyChair:12134,
  author    = {Rohit Mishra},
  title     = {Development and Characterization of a Novel Human Skin and Immune System (hSIS)-Humanized Rodent Model for Studying Skin Pathogen Infections},
  howpublished = {EasyChair Preprint 12134},
  year      = {EasyChair, 2024}}