The Variation Levels of Serum MC3R in the Group of Active TB Patients, Household Contact and Healthy Person as a Control and Correlation with Their Nutritional Status

EasyChair Preprint 4009

Abstract

Gene melanocortin 3 (MC3R) play a role in various biological systems such as body composition, natriuresis, immune function, and circadian rhythms which associated with pathogenesis of tuberculosis. This study investigated the MC3R serum levels on groups of TB status, household contacts, healthy control, and the nutritional status of different groups. The samples of this study were 53 active TB patients, 49 household contacts, and 30 healthy subjects as controls. We analyzed blood samples using IGRA and ELISA Melanocortin 3 test. The results shown average of MC3R levels on different health status groups are active tuberculosis 1259.55 (10.41 to 11279.04); household contacts 535.15 (51.18 to 3757.27); and control 503.26 (10.91 to 1486.58), significantly different with p = 0.028. The average MC3R levels on different nutritional status groups are BMI less 879.26 (10.91 to 11279.04); normal BMI 861.74 (10.41 to 6421.46); excessive BMI 697.28 (70.85 to 4052.48) There is no significant difference with p = 0.817. High MC3R levels in TB patients associated with its role as the main transducer of the anti-inflammatory effect, whereas high MC3R levels on BMI status is insufficiently linked to the physiological role assigned MC3R encodes MSH receptor which is closely related to Leptin excretion.

Keyphrases: BMI, MC3R, Melanocortin-3, Tuberculosis, nutrition

@booklet{EasyChair:4009,
  author    = {Andi Tenriola and Najdah Hidayah and Subair and Irda Handayani and Adnan Ibrahim and Handayani Halik and Muh Nasrum Massi and Rosdiana Natzir and Irawaty Djaharuddin and Jafriati and Tri Damayanti and Andi Tenri Ola Rivai},
  title     = {The Variation Levels of Serum MC3R in the Group of Active TB Patients, Household Contact and Healthy Person as a Control and Correlation with Their Nutritional Status},
  howpublished = {EasyChair Preprint 4009},
  year      = {EasyChair, 2020}}