The Role of GRA7 Protein as a Diagnostic Indicator for Toxoplasmosis in Breast Cancer Women and Thalassemia Patients

EasyChair Preprint 15952

Abstract

Background: Toxoplasmosis is a significant global illness that represents a life-threatening risk to immunocompromised individuals.

Objectives: Estimation of Recominant dense granular protein(GRA7) in serum of breast cancer and thalassemia patients.

Materials and methods: This study was conducted on 50 women with breast cancer and 50 patients with thalassemia who attended the Oncology and Haematology center, and 50 sample collected from healthy people as a control group . Informed consent was obtained from the University of Tikrit/College of medicine and from the Ministry of Health (approval number 22187 on 19/5/2024).

Results

Fifty blood samples were obtained from women diagnosed with breast cancer, and an additional fifty samples were gathered from thalassemia patients admitted to the Oncology and Hematology center, and fifty blood samples were obtained from healthy persons to serve as a control group. The blood samples were properly handled and analyzed for Toxoplasma gondii GRA7, IgM, and IgG using the enzyme-linked immunosorbent assay (ELISA) technique.

Conclusion: toxoplasmosis is a disease commonly associated with cases of immune suppression, such as in individuals with cancer or thalassemia. Additionally, the GR7 protein has been identified as a biomarker useful for detecting the acute stage of toxoplasmosis.

Keyphrases: ELISA, GRA7, Toxoplasmosis

@booklet{EasyChair:15952,
  author    = {Haider Rehman and Zainab Sulaiman},
  title     = {The Role of GRA7 Protein as a Diagnostic Indicator for Toxoplasmosis in Breast Cancer Women and Thalassemia Patients},
  howpublished = {EasyChair Preprint 15952},
  year      = {EasyChair, 2025}}